Improving CBD Water Solubility Through Nanotechnology
CBD has a great number of medicinal properties, including antiepileptic, anxiolytic, neuroprotective and antioxidant activities. It also has a potential in the treatment of various neurological disorders such as Parkinson’s disease, schizophrenia and psychosis, Alzheimer’s disease, and many more . Pharmaceutical-grade, regulated CBD is currently available to patients worldwide as oily capsules, liquid solutions, tablets, sublingual drops, and oromucosal sprays . However, low intrinsic solubility and bioavailability remain major obstacles in their systemic delivery. Read more https://www.biocbdplus.com/collections/water-soluble-cbd/
To increase the bioavailability of CBD, a wide range of formulation strategies have been developed. These include using solubilizers, cosolvency, and hydrotrophy enhancement techniques and novel excipients such as lipid-based systems. However, they are only partially effective, mainly due to the high first-pass metabolism rate of CBD in the body.
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One of the most promising approaches to improving cbd water solubility is using nanotechnology to create CBD-infused products that are both stable and soluble in water. This allows users to get the most out of their product and reduces dosage requirements.
One study developed a nanostructured lipid carrier for the nasal administration of CBD by the hot microemulsion method. Stearic acid and oleic acid were used as solid lipids, and cetylpyridinium chloride and Span 20 were added to enhance the stability and mucoadhesive properties of the carrier. The CBD-loaded lipid carrier showed excellent CBD solubility in water and maintained transparency even after extensive dilution with water, suggesting that the formulation is self-emulsifying. The lecithin-stabilized and HPMCAS-stabilized nanoparticles displayed a burst release, with a six-fold increase in dissolution relative to bulk amorphous CBD.